With the significant potential of immune checkpoint inhibitors in neoadjuvant treatment for breast cancer，a multidisciplinary expert group was formed to develop this consensus based on the existing evidence-based medical evidences and clinical practice through in-depth discussions. The consensus suggests that pre-positioning of immunotherapy can increase the pathological complete response rate of breast cancer and has the potential for long-term survival benefits. Triple negative breast cancer and hormonal receptor-positive/HER-2-negative breast cancer are the preferred groups for neoadjuvant immunotherapy. Corresponding strategies for drug combinations and subsequent treatment plans are provided. Meanwhile，the expert group confirms that the expression of tumor infiltrating lymphocytes can indicate the efficacy of neoadjuvant immunotherapy. The combination of neoadjuvant immunotherapy and targeted therapy is promising in the treatment of triple negative breast cancer and HER-2 positive breast cancer，but further verification is needed.

Colorectal cancer is the second most common malignant tumor in China, and its incidence and mortality rates are on the rise, posing a serious threat to the lives and health of the people. Immunotherapy has brought new breakthroughs in colorectal cancer treatment. However, it is effective only for specific molecular subtypes, controversies persist in multiple aspects. Controversies exist in aspects such as molecular testing, imaging evaluation, selection of advantageous populations, and treatment strategies, which have caused troubles for clinicians in making diagnostic and therapeutic decisions. To standardize and guide the clinical practice of colorectal cancer immunotherapy, the Immunology Group of Colorectal Cancer Professional Committee of the Chinese Medical Doctor Association organized multidisciplinary experts to develop this consensus. Based on the disease characteristics of colorectal cancer in the Chinese population and China’s existing diagnostic and treatment systems, the consensus recommendations are grounded in evidence-based medical research. The consensus focuses on imaging evaluation, perioperative treatment, treatment of metastatic colorectal cancer(mCRC), and future directions, while formulating targeted and practical recommendations. The consensus aims to optimize clinical practice, improve disease control, enhance patient quality of life, and prolong survival.

Colorectal cancer has exhibited a persistently rising incidence and mortality rate in China, emerging as a critical public health challenge. For patients with locally advanced rectal cancer, neoadjuvant radiotherapy remains the standard treatment recommended by domestic and international guidelines. Intraoperative radiation therapy (IORT), an modality integrating radiotherapy with surgical intervention, has gained prominence in recent years due to its precision in target localization, enhanced local control efficacy, and reduced risk of perioperative tissue damage. However, unresolved issues persist regarding standardized indications, technical implementation protocols, efficacy evaluation systems, and long-term outcome validation, necessitating evidence-based consensus and multicenter clinical research. To address these challenges,‌ Intraoperative Radiotherapy Working Group, Colorectal Cancer Professional Committee of the Chinese Medical Doctor Association convened multidisciplinary experts. Synthesizing global evidence and clinical experience, the group formulated the expert consensus on intraoperative radiation therapy for colorectal cancer (2025 Edition). This consensus aims to serve as a reference for clinical practice and to advance standardized diagnostic and therapeutic protocols, fostering high-quality development in this field.

In China, colorectal cancer ranks second in incidence and fourth in mortality among all malignant tumors. The incidence of ovarian metastasis in female colorectal cancer patients is increasing. Characterized by insidious symptoms, rapid progression, and suboptimal sensitivity to conventional systemic therapies, its clinical management remains controversial. To address these challenges, under the guidance of the Colorectal Cancer Professional Committee of the Chinese Medical Doctor Association, authoritative experts in related fields conducted multidisciplinary discussions to revise and update the "Chinese expert consensus on diagnosis and treatment of colorectal cancer with ovarian metastasis (2020 Edition)". This consensus aims to guide and standardize the diagnostic and therapeutic protocols for such patients, establish precise, personalized, and comprehensive treatment goals and strategies, and ultimately enhance the overall diagnosis and treatment standards for colorectal cancer, and prolong survival and improve quality of life for colorectal cancer patients in China.

Second-degree burns are a common type of burn in clinical practice. Currently, multiple types of dressings and topical medications can promote the healing of second-degree burn wounds. Among these, growth factors play a synergistic role in the wound healing process by promoting cell proliferation， migration， and differentiation， as well as enhancing angiogenesis and collagen synthesis. Although growth factor preparations have been used in clinical practice for many years， the emergence of new types and formulations of growth factors led to more prominent related controversies. How to select appropriate growth factors and apply timely and effectively for the treatment of burn wounds is a challenge in clinical application. This article compiles the consensus reached by experts in the field of burns and related areas on the use of growth factors for second-degree burn wounds， including the types， application scope， usage duration， and scar prevention， aiming to provide guiding recommendations for the use of growth factors in the treatment of second-degree burn wounds.

The "Expert consensus on diagnosis and treatment of acute biliary tract infection in the elderly (2025 edition)" was compiled and organized by the Hepatobiliary Pancreatic Surgery Committee of Chinese Aging Well Association. Acute biliary tract infections in the elderly are common among the acute abdominal diseases in the elderly, with atypical clinical manifestations, rapid progression and high fatality rate. The consensus puts forward targeted recommendations around multiple aspects such as the diagnosis, severity assessment, imaging examination, systemic assessment, rational application of antibiotics, intensive care treatment, nutritional support, surgical treatment and endoscopic treatment of acute biliary tract infections in the elderly. The consensus emphasizes that the diagnosis of elderly patients should be combined with comprehensive assessment of clinical manifestations, laboratory tests and imaging examinations, and that treatment should be individualized, and attach importance to multidisciplinary collaboration during the perioperative period. The consensus provides important references for the standardized diagnosis and treatment of acute biliary tract infections in the elderly.