To evaluate the features of carotid web (CW) by ultrasonography.

A total of 66 patients with CW were retrospectively enrolled from January 2018 to June 2019 at Xuanwu Hospital, Capital Medical University. All patients were examined by both ultrasonography and CTA, and were divided into either a<50% stenosis group (54 cases) or a ≥50% stenosis group (12 cases). The ultrasonographic characteristics of CW, including the length, thickness, direction (forward or backward to the flow), acute angle between the web and carotid wall, and thrombus between the web and carotid wall were compared between the two groups. The stenosis degrees of carotid artery were compared between patients with and without ischemic stroke.

Forty-two (42/66, 63.6%) patients were diagnosed with CW by initial CDFI examination, of whom 21 (21/66, 31.8%) were diagnosed with ulcerative plaque and 3 (3/66, 4.5%) were diagnosed with carotid dissection at first but confirmed by second examination. There were no differences in the web length, thickness, direction, or thrombus detected between the two groups (P>0.05). The angle between the web and carotid wall in the<50% stenosis group was significantly smaller than that of the ≥50% stenosis group (median angel 39o vs 73o, P=0.002), and the percentage of patients with an angle≤ 60o in the<50% stenosis group was significantly higher than that of the ≥50% stenosis group (74.1% vs 41.7%, P=0.042). The diameter of the residual carotid artery at CW location in the<50% stenosis group was significantly larger and peak systolic velocity was significantly higher in the<50% stenosis group than in the≥50% stenosis group (P<0.001). The stenosis degrees of carotid artery were not statistically different between patients with and without ischemic stroke (P=0.321).

Ultrasonography can be used to evaluate the characteristics of carotid web in 2D and color mode. When the angle between the CW and carotid wall is large, the carotid artery stenosis ≥ 50% is more likely to happen, but carotid artery stenosis is not the main cause of ischemic stroke.

The aim of the present study was to evaluate the efficiency of sling exercise, therapeuticultrasound, therapeuticultrasound and sling exercise in patients to alleviate pain and improve lumbar function with lumbar disc herniation.

Individuals were selected from a list of patients being followed at the department of Rehabilitation in the third hospital of Hebei Medical University. 30 patients who were diagnosed with lumbar disc herniation were collected, the diagnoses were established upon medical history, physical examination, and results of imaging studies. The patients were randomly divided into three groups: therapeuticultrasound group received 14 sessions of ultrasonic therapy to the lumbar region, Sling exercise group received 14 sessions of sling exercise, and therapeuticultrasound and sling exercise group received therapeuticultrasound and sling exercise therapy 14 sessions of therapeuticultrasound to the lumbar region,7 sessions per week, 2 weeks. The VAS and ODI were compared with the assessment of the patients before and at the end of the therapy.

At the end of treatment, three groups VAS scores (F=3.069, P=0.043) and ODI scores (t=12.676, P<0.001) was lower than that at the beginning of treatment (P<0.05), at the end of treatment the VAS scores (F=59.400, P<0.001) and of the ODI scores (t=12.737, P<0.001) of ultrasonic and sling exercise therapy group was lower than the other group, the difference is significantly.

All three groups could reduce pain and improve lumbar function, and the ultrasonic and sling exercise therapy was most effective for lumbar disc herniation treatment in the three groups.

To analyze the treatment of different types of traumatic cerebral infarction in children, and explore its pathogenesis in combination with literature so as to improve the cure rate and reduce disability rate.

The clinical data of 42 cases of traumatic cerebral infarction in children were retrospectively analyzed in The Hospital of 81^st Group Army PLA from January 2015 to December 2019. The diagnosis of traumatic cerebral infarction in children was made by CT scan and MRI scan. According to different conditions, children with traumatic cerebral infarction were classified, and different treatment strategies were selected. Children with lacunar infarction were treated with calcium antagonists and neurotrophic drugs, supplemented by hyperbaric oxygen and exercise rehabilitation. The children of focal cerebral infarction and complex cerebral infarction treated by junior dehydrant and hormone also included the calcium antagonist and nutritional nerve drugs. The therapeutic regimen perhaps adjusted by the evolution of the disease. The children of extensive cerebral infarction underwent emergency cranial decompression, and was treated by reducing intracranial pressure and preventing complications after operation. The treatment results and recovery were observed.

In 42 cases of traumatic cerebral infarction in children, 35 cases (83.3%) were good recovery, 4 cases (9.5%) were moderate disability, 2 cases (4.8%) were severe disability, 1 case (2.4%) died, and no vegetative state. The good recovery rate of lacunar infarction was 100%, that of focal cerebral infarction was 62.5%, that of mixed cerebral infarction was 60%, and that of extensive cerebral infarction was 50%.

It is of great significance to improve the therapeutic effect and prognosis of children with traumatic cerebral infarction to adopt different treatment schemes for different types of cerebral infarction.

To characterize the patients with supratentorial hypertensive intracerebral hemorrhage (ICH) in the Tibetan Plateau over an altitude of 4000 meters.

A total of 68 cases with supratentorial hypertensive ICH were retrospectively included in Ali Regional People’s Hospital from January 2017 to September 2018. The clinical and laboratory data were collected. A simple linear correlation analysis was applied to analyze the correlation between the amount of bleeding and sex, age, nationality, time from onset , systolic blood pressure (SBP), diastolic blood pressure (DBP), hemoglobin (Hb), serum triglyceride (TG), and cholesterol. According to computed tomography (CT) findings, 68 cases were divided into the basal ganglia ICH group (33 cases) and the lobar ICH group (35 cases). The characteristics between two groups were analyzed using t-test or χ² test.

The data of sex, age, nationality, time from onset, SBP, DBP, Hb, TG, and cholesterol of 68 cases on admission did not show any definitive correlation with the hematoma volumes (P＞0.05). The SBP and DBP of patients in the basal ganglia ICH group were significantly higher than that in the lobar ICH group, respectively [(184.9±28.5) mmHg vs (164.6±24.4) mmHg; (113.0±18.1) mmHg vs (103.0±18.4) mmHg] (t=0.499, 0.486; P=0.002, 0.033).

The relevant factors of hematoma volumes in patients with ICH in plateau area were not yet clear. Diastolic and systolic blood pressure of patients in the basal ganglia ICH group was higher than that in those in lobar ICH group.

To compare the efficacy evaluation of electrospun composite biomaterials and a porcine small intestine submucosa mesh for hernia repair.

A randomized, single-blind, controlled multicenter trial was performed in 3 hospitals in Shanghai. Eligible adult patients with primary unilateral reducible groin hernias were randomly assigned (1∶1) to electrospun composite biomaterials (experimental group) or porcine small intestine submucosa (control group) mesh groups. Patients were treated with the tARB technique and assessed at 1,3 and 6 months after the surgery. The primary endpoint was hernia recurrence. The secondary endpoints were postoperative complications including groin pain and operative site infections.

172 patients were assigned to experimental (n=86) and control (n=86) groups. At 6 months follow-up, postoperative complications occurred in 5 patients (5/86, 5.95%) and 2 (2/86, 2.35%) patients in the control and experimental groups, respectively (P>0.05). There was no significant difference in VAS or SVS score between the two groups.

We demonstrate that electrospun composite biomaterial mesh can be used as a ideal choice for inguinal hernia repair. Electrospun composite biomaterial has the characteristics of low recurrence rate, absorbability and long-term comfort.It can be further applied in clinical practice in the future.

Pancreaticoduodenectomy(PD)remains one of the most complicated hepatobiliary operations. The development of minimally invasive surgery for PD has always been an hot spot. Laparoscopic pancreaticoduodenectomy(LPD) has not been widespread carried out due to its difficulty and long learning curve. LPD accounts for 9% of all PD, according to the National Cancer Data base. Compared with laparoscopic surgery, robotic surgery system has significant advantages in the field of minimally invasive PD, including stereotactic amplified vision, filtering hand tremor and simulating the wrist. The article would review the surgical techniques and notes, which could provide clinical reference for other surgeons.

Early diagnosis of gastric cancer is crucial for improving patient survival rates and prognosis. However, traditional endoscopic diagnosis is often hindered by the endoscopist's experience and visual recognition ability, leading to suboptimal detection rates. In recent years, artificial intelligence (AI) technology based on deep learning convolutional neural networks (CNNs) has made significant progress in endoscopic image recognition, greatly enhancing both diagnostic accuracy and efficiency. This article aims to review the current status and future clinical prospects of AI-assisted endoscopy in diagnosing early gastric cancer.

Low back pain (LBP) has a high incidence rate and is the leading cause of activity limitation among people under 45 years old. Its causes include abnormal muscle function, ligament injury, and other factors. Traditional imaging examinations have limitations such as radiation exposure, high cost, or static assessment. Musculoskeletal ultrasound, with advantages such as dynamic observation, portability, and no radiation, has gradually become a key technology in diagnosis and treatment. This article systematically reviews the progress in applications of ultrasound technology in the diagnosis and treatment of lumbosacral pain. In terms of etiological diagnosis, ultrasound can assess soft tissues (multifidus muscle, erector spinae muscle function, and fascia lesions such as thoracolumbar fascia), bone structures (lumbar facet joints and sacroiliac joints), and nerve compression (radeiculopathy and nerve abnormalities related to lumbar disc herniation) through multimodal techniqus, providing a basis for etiological identification. Regarding therapeutic applications, ultrasound-guided techniques enable precise localization and are utilized across a range of interventions targeting muscles, ligaments, and fascia (drug injection and acupuncture); joints and spinal structures (intra-articular injection and radiofrequency neurotomy); and nerve roots (drug delivery and ozone therapy). This approach contributes to reduced complication rates and improved clinical outcomes. Ultrasound technology has advantages such as non-invasive dynamic assessment, improved treatment accuracy, simple operation, and low cost. However, it has limitations such as reliance on the operator's experience, insufficient imaging of deep tissues, and the need for more high-quality research verification. In the future, it can be combined with shear wave elastography and shear wave dispersion imaging technologies to assess the elasticity and viscosity of the lumbosacral muscle fascia to improve disease assessment. In conclusion, ultrasound technology provides an important tool for the diagnosis and treatment of lumbosacral pain. With the development of technology and the accumulation of evidence, it is expected to become one of the core diagnostic and therapeutic methods in this field.

Aplastic anemia (AA) is an immune-mediated hematopoietic failure disease, characterized by pancytopenia in peripheral blood and hypocellular bone marrow without abnormal hyperplasia or fibrosis. Its main clinical manifestations are anemia, bleeding, and infection, and both its incidence and mortality rates are notably high. Investigating the pathogenesis of AA is therefore crucial for identifying potential therapeutic targets at diagnosis or after treatment. Single-cell RNA sequencing (scRNA-seq) technology overcomes the limitation of traditional sequencing, which captures only average transcriptional levels acorss cell populations, by enabling precise transcriptome profiling at single-cell resolution. In contrast to conventional detection methods, scRNA-seq can assess heterogeneity within cell populations and construct gene expression maps for individual cells, thereby helping to elucidate the complex molecular networks underlying intercellular crosstalk. Considering the strengths and limitations of commonly used scRNA-seq platforms, this article reviews the applications of scRNA-seq technology in studying AA.

To explore the similarities and differences in the biological phenotypes and cytotoxicity of resident and expanded natural killer cells derived from mononuclear cells of human bone marrow between healthy donors (HD) and patients with B-cell acute lymphoblastic leukemia (B-ALL) .

Bone marrow blood of HD and B-ALL was collected, and mononuclear cells were enriched by density gradient centrifugation. Flow cytometry was used to analyze the phenotypes of resident NK cells (HD-NK and BALL-NK) in the two types of blood. Then, with the aid of our well-established 14-day "3ILs"-based (short for IL-2, IL-15, IL-18) culture system for in vitro high-efficient activation and expansion of NK cells, we conducted cell counting, flow cytometry analysis and in vitro co-culture killing tests to compare the phenotypes and cytotoxicity of expanded HD-NK cells (eHD-NK) and expanded BALL-NK cells (eBALL-NK) in bone marrow blood. Comparisons between two groups were performed using independent samples t-test. Comparisons among the four groups (HD-NK, eHD-NK, BALL-NK, and eBALL-NK) were conducted using two-way repeated measures ANOVA, followed by Bonferroni's post hoc test for pairwise comparisons.

Compared with the healthy donor (HD) group, the proportion of total CD3^-CD56⁺ NK cells in the non-activated, expanded resident NK cell population from patients with B-cell acute lymphoblastic leukemia (B-ALL) was significantly lower [ (4.21 ± 0.92) % vs (14.25 ± 1.15) %]. In addition, the frequencies of activated NK cell subsets were reduced, including CD16⁺ NK cells [ (46.82 ± 2.96) % vs (67.87 ± 2.12) %], NKG2D⁺ NK cells [ (22.45 ± 2.12) %vs (50.82 ± 5.65) %], and NKp46⁺ NK cells [ (7.66 ± 1.73) % vs (17.27 ± 1.75) %]. Following in vitro activation and expansion, the proportion of total NK cells was significantly increased in both the expanded HD-NK (eHD-NK) group and the expanded B-ALL-derived NK (eBALL-NK) group [ (61.52 ± 3.18) % vs (14.25 ± 1.15) %]; (24.63 ± 2.07) % vs (4.21 ± 0.92) %]. Moreover, the eHD-NK group exhibited higher proportions of total NK cells [ (61.52 ± 3.18) % vs (24.63 ± 2.07) %] and multiple activated NK cell subsets than the eBALL-NK group, including NKG2D⁺ NK cells [ (80.63 ± 2.03) % vs (57.83 ± 8.55) %], CD25⁺ NK cells [ (37.45 ± 3.21) %vs (20.90 ± 5.15) %], and NKp46⁺ NK cells [ (27.23 ± 2.30) % vs (9.51 ± 0.98) %]. Cell viability analysis demonstrated that the efficiency of in vitro activation and expansion of total NK cells was higher in the HD group than in the B-ALL group. Compared with the eHD-NK group, the eBALL-NK group showed significantly higher proportions of apoptotic cells, including Annexin V⁺7-AAD- cells [ (4.50 ± 0.35) % vs (2.72 ± 0.43) %] and Annexin V⁺ cells [ (5.13 ± 0.62) % vs (3.29 ± 0.58) %], while no significant differences in cell cycle distribution were observed between the two groups. In vitro cytotoxicity co-culture assays revealed that eHD-NK cells exhibited stronger cytotoxic activity against the tumor cell lines Nalm6 and U937 compared with eBALL-NK cells.

Compared with HDs, bone marrow–derived resident and activated NK cells from B-ALL patients exhibited reduced proportions, diminished activated subpopulation content, impaired in vitro activation capacity, decreased cellular viability, and attenuated cytotoxicity. This study provides valuable reference for subsequent investigations into the underlying pathogenic mechanisms and the development of clinical therapeutic strategies.

Exploring the ameliorative effects of blueberry extract on atopic dermatitis (AD) and elucidating its mechanisms of action through changes in skin microbiota, restoration of barrier function, and improvement of Th2-type inflammation.

The AD mouse model was induced by topical application of the vitamin D3 analog calcipotriol (MC903). Ear thickness was measured in a double-blind manner on days 1, 3, 5, 7, 10, 12, and 14, and scratching episodes within 30 minutes were recorded on day 14. Ear tissue samples were collected for hematoxylin-eosin (HE) staining and epidermal thickness measurement. The mRNA expression of inflammatory cytokines (IL-33, IL-22, TSLP, TNF-α, IL-6, and IL-1β) was detected by RT-qPCR. 16S rRNA sequencing was used to analyze the effect of blueberry extract on the microbial community in AD mice. A cellular model was established by stimulating human keratinocytes (HaCaT) with lipopolysaccharide (LPS, 20 μg/mL). The effect of different concentrations of blueberry extract on cell viability was assessed using the CCK-8 assay. Expression of IL-33, TSLP, and IL-4Rα proteins were detected by Western blot. The composition of blueberry extract was identified by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Comparisons between two groups were performed using the independent samples t-test. Comparisons among multiple groups were conducted using either one-way ANOVA or repeated-measures ANOVA, as appropriate. Post hoc pairwise comparisons were carried out with Tukey's test.

Compared with the model group, blueberry extract significantly alleviated ear swelling in AD mice, reduced scratching frequency [ (9.00 ± 0.89) vs (14.67 ± 2.06) times] and epidermal thickness [ (37.78 ± 2.68) vs (54.90 ± 10.09) μm] (all P < 0.05). Blueberry extract downregulated the expression of Th2 inflammatory cytokines and pro-inflammatory factors mRNA. Compared with the model group, the expression levels of IL-33 (0.95 ± 0.18 vs 1.36 ± 0.23), TSLP (27.12 ± 4.73 vs 39.09 ± 4.61), IL-22 (1.98 ± 0.45 vs 3.43 ± 0.36), and IL-1β (4.47 ± 1.44 vs 20.26 ± 3.30) mRNA were decreased in treatment group (P < 0.05). 16S rRNA analysis revealed that blueberry extract mitigated microbial community dysbiosis and loss of diversity, inhibiting the proliferation of pathogenic bacteria such as Streptococcus, Staphylococcus, and Enterobacter. In the cellular experiments, compared with the LPS-induced model group, treatment with 80 μmol/L blueberry extract significantly reduced the protein expression of IL-4Rα (1.64 ± 0.31 vs 5.90 ± 0.24), IL-33 (0.90 ± 0.15 vs 4.27 ± 0.41), and TSLP (0.15 ± 0.07 vs 5.61 ± 0.40), as well as the mRNA expression of IL-4Rα (2.57 ± 0.54 vs 13.20 ± 3.43), IL-33 (2.00 ± 0.44 vs 5.40 ± 1.24), and TSLP (1.47 ± 0.06 vs 4.04 ± 0.21) (all P < 0.05). Further mass spectrometry identification indicated that delphinidin might be the core active component in blueberry extract.

Blueberry extract significantly alleviated symptoms in the AD mouse model by modulating the skin microbiota, restoring barrier function, suppressing Th2-type inflammatory responses, and reducing inflammatory cytokine expression in HaCaT cells, with delphinidin identified as its potential core active constituent.

The neddylation process covalently conjugates neural precursor cell expressed developmentally downregulated 8 (NEDD8) to substrate proteins through a continuous enzymatic cascade reaction, which affects the stability, conformation, and function of substrate proteins, thereby regulating numerous downstream biological processes. The neddylation process is associated with the progression and prognosis of various types of tumors. As the only currently known activating enzyme in the neddylation process, NEDD8-activating enzyme (NAE) is an important target for the development of anti-cancer drugs. MLN4924, a selective NAE inhibitor, has good therapeutic effects on various types of solid tumors and hematological malignancies. Currently, 41 clinical trials have entered phases Ⅱ/Ⅲ, indicating promising application prospects. The drug resistance of tumor cells is an important cause of treatment failure in cancer patients. Once tumor cells acquire drug resistance, it will significantly affect the prognosis of patients. This article reviews the current research progress on the resistance mechanism of MLN4924 and the measures to address the problem of resistance to it.

Renal fibrosis is a multifactorial-driven pathological process involving intrarenal inflammation, cellular proliferation, and excessive deposition of collagen and fibronectin. Without intervention, this process can progress to chronic kidney disease (CKD) and may ultimately lead to end-stage renal disease. Stem cell-derived exosomes represent an emerging therapeutic strategy for renal fibrosis. Functioning as nanoscale extracellular vesicles (EVs), exosomes carry bioactive molecules that can be taken up by local or distal cells. They serve as mediators of intercellular communication while also delivering therapeutic payloads (e.g., microRNAs, proteins). In animal models of kidney disease, stem cell-derived exosomes have been demonstrated to effectively attenuate inflammation, suppress fibroblast activation, and reduce collagen production in the renal interstitium, thereby delaying fibrosis progression. This review summarizes the mechanisms underlying the antifibrotic effects of exosomes derived from various stem cell sources used as therapeutic agents for renal fibrosis. It also outlines future translational research directions and strategies aimed at enhancing the therapeutic efficacy of stem cell-derived exosomes.

Poor graft function (PGF) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a severe post-transplant complication affecting patient prognosis, which often leads to infections and an elevated risk of hemorrhagic events. The pathogenesis of PGF is multifactorial, involving mechanisms such as functional impairment of donor-derived stem cells, injury to the bone marrow microenvironment, and dysregulation of immune homeostasis. Current therapeutic strategies for PGF include mesenchymal stem cell infusions, CD34⁺ cell reinfusion, secondary transplantation as well as drug intervention such as statins and hematopoietic growth factors, repairing the microenvironment and promoting hematopoietic reconstitution. This article reviews the recent advances in understanding the pathophysiological mechanisms and therapeutic management of PGF.

Diabetic nephropathy (DN) is the most common microvascular complications of diabetes and serves as a leading cause of end-stage renal disease, which is caused by complex mechanisms, including cellular damage induced by hyperglycemia, dysregulated inflammatory and immune responses, renal fibrosis, and vascular injury. Although conventional treatments can delay the progress of the disease, they often fail to effectively halt the irreversible deterioration of renal function. Consequently, exploring practical and effective therapeutic strategies is a key issue that needs to be urgently addressed. In recent years, mesenchymal stem cells (MSCs) and their exosomes have garnered significant research interest due to their capacities for self-renewal and multi-lineage differentiation. Preclinical studies indicate that MSCs exhibit potential in restoring renal structure and function through various mechanisms, such as cytoprotection, modulation of inflammation and immune responses, inhibition of fibrosis, epigenetic regulation, and regulation of the gut–kidney axis. Multiple administration routes, including intravenous, renal arterial, and local injection, have demonstrated considerable therapeutic efficacy. Nonetheless, clinical research remains in the nascent stages, with only small-scale trials and case reports indicating that the MSCs have certain potential for renal protection. Their long-term safety, standardized treatment regimens, and the efficacy differences among MSCs from different sources still require further research and verification.

Mesenchymal stem cells (MSCs) have shown broad application prospects in the field of regenerative medicine due to their strong self-renewal ability, low immunogenicity and multi-directional differentiation potential. However, during the in vitro expansion, due to the differences between the culture environment and the physiological state in vivo, MSCs are prone to replicative senescence, which is manifested as slowed proliferation ability, reduced differentiation capacity and weakened function, thereby limiting their clinical transformation and application. Recently, significant efforts have been made to develop effective strategies to delay MSC aging and have made significant progress in gene modification, optimization of culture systems, and application of biomaterials. This review highlights recent advances in approaches to delay senescence in MSCs, aiming to provide a theoretical basis for improving the quality of in vitro culture of MSCs and maintaining their functional characteristics and broaden the scope of MSC applications in tissue engineering and cell-based therapies.

To investigate the perinatal management and maternal and neonatal outcomes of 14 cases of delayed interval delivery in multiple pregnancies.

A retrospective analysis was conducted on 14 cases of multiple pregnancies that underwent delayed interval delivery at our hospital from 2017 to 2024. Data collected included gestational age at delivery, delivery interval, perinatal management, and maternal and neonatal outcomes.

Among the 14 cases, 12 were conceived via in vitro fertilization-embryo transfer, and 2 via ovulation induction with timed intercourse. There were 12 twin pregnancies and 2 triplet pregnancies. The mean gestational age at delivery of the first fetus was 21^{+ 2} weeks, the mean delayed interval for the remaining fetus(es) was 47.42 days (2-127 days), and the mean gestational age at delivery of the last fetus(es) was 28^{+ 6} weeks. A total of 13 live infants were delivered, with a mean birth weight of 1 531.53 g (800-3 090 g). Among these, 12 newborns were transferred to the neonatal intensive care unit (NICU) after delivery, and 1 was transferred to the NICU on due to neonatal jaundice three days after birth. The mean length of NICU stay was 45.85 days (1-89 days). There were 12 vaginal deliveries, including 3 miscarriages, and 2 cesarean deliveries. All patients received prophylactic antibiotics and uterine contraction inhibitors; none underwent cervical cerclage. Placental pathology was available for 10 patients, revealing 1 case of placental abruption, 8 cases of stage Ⅰ-Ⅱ chorioamnionitis, and 2 cases with no inflammatory changes.

Delayed interval delivery is a specialized management strategy for multiple pregnancies. Its successful implementation improves the survival rate of the remaining fetus(es), reduces neonatal mortality, and contributes to better neonatal outcomes.

探讨妊娠合并乳腺癌伴胎盘转移患者的临床特点、孕期诊疗要点、母胎管理策略和胎盘转移机制，为降低此类患者不良结局提供参考。

回顾性分析广州医科大学附属第三医院收治的1例妊娠合并乳腺癌伴胎盘转移患者的临床资料，并结合文献进行讨论。

患者有左侧乳腺浸润性癌ⅡB期病史，术后辅助治疗2年后自行停药。本次意外妊娠后孕期左侧乳腺癌复发，伴右侧乳腺转移。孕30^＋6周因心功能Ⅳ级行剖宫产术，术后病理证实胎盘绒毛间隙癌转移，脐带、羊水无癌细胞，患者术后16 d因多器官功能衰竭死亡，胎儿随访12个月无异常。

妊娠合并乳腺癌伴胎盘转移极为罕见，预后差。本例确诊胎盘转移但胎儿未受累，为研究胎盘"屏障"作用机制提供了宝贵的人类体内证据。应加强乳腺癌术后随访及妊娠期监测，强调多学科协作与个体化管理，以改善母儿结局。