To evaluate the features of carotid web (CW) by ultrasonography.

A total of 66 patients with CW were retrospectively enrolled from January 2018 to June 2019 at Xuanwu Hospital, Capital Medical University. All patients were examined by both ultrasonography and CTA, and were divided into either a<50% stenosis group (54 cases) or a ≥50% stenosis group (12 cases). The ultrasonographic characteristics of CW, including the length, thickness, direction (forward or backward to the flow), acute angle between the web and carotid wall, and thrombus between the web and carotid wall were compared between the two groups. The stenosis degrees of carotid artery were compared between patients with and without ischemic stroke.

Forty-two (42/66, 63.6%) patients were diagnosed with CW by initial CDFI examination, of whom 21 (21/66, 31.8%) were diagnosed with ulcerative plaque and 3 (3/66, 4.5%) were diagnosed with carotid dissection at first but confirmed by second examination. There were no differences in the web length, thickness, direction, or thrombus detected between the two groups (P>0.05). The angle between the web and carotid wall in the<50% stenosis group was significantly smaller than that of the ≥50% stenosis group (median angel 39o vs 73o, P=0.002), and the percentage of patients with an angle≤ 60o in the<50% stenosis group was significantly higher than that of the ≥50% stenosis group (74.1% vs 41.7%, P=0.042). The diameter of the residual carotid artery at CW location in the<50% stenosis group was significantly larger and peak systolic velocity was significantly higher in the<50% stenosis group than in the≥50% stenosis group (P<0.001). The stenosis degrees of carotid artery were not statistically different between patients with and without ischemic stroke (P=0.321).

Ultrasonography can be used to evaluate the characteristics of carotid web in 2D and color mode. When the angle between the CW and carotid wall is large, the carotid artery stenosis ≥ 50% is more likely to happen, but carotid artery stenosis is not the main cause of ischemic stroke.

The aim of the present study was to evaluate the efficiency of sling exercise, therapeuticultrasound, therapeuticultrasound and sling exercise in patients to alleviate pain and improve lumbar function with lumbar disc herniation.

Individuals were selected from a list of patients being followed at the department of Rehabilitation in the third hospital of Hebei Medical University. 30 patients who were diagnosed with lumbar disc herniation were collected, the diagnoses were established upon medical history, physical examination, and results of imaging studies. The patients were randomly divided into three groups: therapeuticultrasound group received 14 sessions of ultrasonic therapy to the lumbar region, Sling exercise group received 14 sessions of sling exercise, and therapeuticultrasound and sling exercise group received therapeuticultrasound and sling exercise therapy 14 sessions of therapeuticultrasound to the lumbar region,7 sessions per week, 2 weeks. The VAS and ODI were compared with the assessment of the patients before and at the end of the therapy.

At the end of treatment, three groups VAS scores (F=3.069, P=0.043) and ODI scores (t=12.676, P<0.001) was lower than that at the beginning of treatment (P<0.05), at the end of treatment the VAS scores (F=59.400, P<0.001) and of the ODI scores (t=12.737, P<0.001) of ultrasonic and sling exercise therapy group was lower than the other group, the difference is significantly.

All three groups could reduce pain and improve lumbar function, and the ultrasonic and sling exercise therapy was most effective for lumbar disc herniation treatment in the three groups.

To analyze the treatment of different types of traumatic cerebral infarction in children, and explore its pathogenesis in combination with literature so as to improve the cure rate and reduce disability rate.

The clinical data of 42 cases of traumatic cerebral infarction in children were retrospectively analyzed in The Hospital of 81^st Group Army PLA from January 2015 to December 2019. The diagnosis of traumatic cerebral infarction in children was made by CT scan and MRI scan. According to different conditions, children with traumatic cerebral infarction were classified, and different treatment strategies were selected. Children with lacunar infarction were treated with calcium antagonists and neurotrophic drugs, supplemented by hyperbaric oxygen and exercise rehabilitation. The children of focal cerebral infarction and complex cerebral infarction treated by junior dehydrant and hormone also included the calcium antagonist and nutritional nerve drugs. The therapeutic regimen perhaps adjusted by the evolution of the disease. The children of extensive cerebral infarction underwent emergency cranial decompression, and was treated by reducing intracranial pressure and preventing complications after operation. The treatment results and recovery were observed.

In 42 cases of traumatic cerebral infarction in children, 35 cases (83.3%) were good recovery, 4 cases (9.5%) were moderate disability, 2 cases (4.8%) were severe disability, 1 case (2.4%) died, and no vegetative state. The good recovery rate of lacunar infarction was 100%, that of focal cerebral infarction was 62.5%, that of mixed cerebral infarction was 60%, and that of extensive cerebral infarction was 50%.

It is of great significance to improve the therapeutic effect and prognosis of children with traumatic cerebral infarction to adopt different treatment schemes for different types of cerebral infarction.

To characterize the patients with supratentorial hypertensive intracerebral hemorrhage (ICH) in the Tibetan Plateau over an altitude of 4000 meters.

A total of 68 cases with supratentorial hypertensive ICH were retrospectively included in Ali Regional People’s Hospital from January 2017 to September 2018. The clinical and laboratory data were collected. A simple linear correlation analysis was applied to analyze the correlation between the amount of bleeding and sex, age, nationality, time from onset , systolic blood pressure (SBP), diastolic blood pressure (DBP), hemoglobin (Hb), serum triglyceride (TG), and cholesterol. According to computed tomography (CT) findings, 68 cases were divided into the basal ganglia ICH group (33 cases) and the lobar ICH group (35 cases). The characteristics between two groups were analyzed using t-test or χ² test.

The data of sex, age, nationality, time from onset, SBP, DBP, Hb, TG, and cholesterol of 68 cases on admission did not show any definitive correlation with the hematoma volumes (P＞0.05). The SBP and DBP of patients in the basal ganglia ICH group were significantly higher than that in the lobar ICH group, respectively [(184.9±28.5) mmHg vs (164.6±24.4) mmHg; (113.0±18.1) mmHg vs (103.0±18.4) mmHg] (t=0.499, 0.486; P=0.002, 0.033).

The relevant factors of hematoma volumes in patients with ICH in plateau area were not yet clear. Diastolic and systolic blood pressure of patients in the basal ganglia ICH group was higher than that in those in lobar ICH group.

To compare the efficacy evaluation of electrospun composite biomaterials and a porcine small intestine submucosa mesh for hernia repair.

A randomized, single-blind, controlled multicenter trial was performed in 3 hospitals in Shanghai. Eligible adult patients with primary unilateral reducible groin hernias were randomly assigned (1∶1) to electrospun composite biomaterials (experimental group) or porcine small intestine submucosa (control group) mesh groups. Patients were treated with the tARB technique and assessed at 1,3 and 6 months after the surgery. The primary endpoint was hernia recurrence. The secondary endpoints were postoperative complications including groin pain and operative site infections.

172 patients were assigned to experimental (n=86) and control (n=86) groups. At 6 months follow-up, postoperative complications occurred in 5 patients (5/86, 5.95%) and 2 (2/86, 2.35%) patients in the control and experimental groups, respectively (P>0.05). There was no significant difference in VAS or SVS score between the two groups.

We demonstrate that electrospun composite biomaterial mesh can be used as a ideal choice for inguinal hernia repair. Electrospun composite biomaterial has the characteristics of low recurrence rate, absorbability and long-term comfort.It can be further applied in clinical practice in the future.

Pancreaticoduodenectomy(PD)remains one of the most complicated hepatobiliary operations. The development of minimally invasive surgery for PD has always been an hot spot. Laparoscopic pancreaticoduodenectomy(LPD) has not been widespread carried out due to its difficulty and long learning curve. LPD accounts for 9% of all PD, according to the National Cancer Data base. Compared with laparoscopic surgery, robotic surgery system has significant advantages in the field of minimally invasive PD, including stereotactic amplified vision, filtering hand tremor and simulating the wrist. The article would review the surgical techniques and notes, which could provide clinical reference for other surgeons.

To retrospectively analyze the clinical data of patients undergoing robot-assisted segmentectomy since the implementation of the Da Vinci robotic surgical system at a single center, summarizing its safety, feasibility, and perioperative outcomes, thereby providing data support for the promotion and optimization of this technique.

A total of 472 patients who underwent robot-assisted anatomical segmentectomy in Shanghai Pulmonary Hospital between October 2020 and December 2023 were included. Baseline patient characteristics, surgical details, perioperative indicators, and complications were collected. The primary endpoint was perioperative complications. Secondary endpoints included conversion rate to thoracotomy, operative time, intraoperative blood loss, rates of 30-day readmission and 90-day mortality.

All 472 procedures were completed successfully without conversion to thoracotomy or mortality. The mean patient age was (57.45±11.88) years. The overall surgical volume showed an increasing trend. The dual-port approach was predominant (72.0%), with a rising proportion of single-port surgeries. The mean operative time was (100.19±41.93) min. Fitting of the learning curve was performed based on operative time. Intraoperative blood loss was <100 mL in 98.7% of cases, with only one patient (0.2%) requiring intraoperative blood transfusion. The mean postoperative hospital stay was (3.29±1.54) days. The overall complication rate was low, mainly consisting of persistent air leak (18 patients, 3.8%). The 30-day readmission rate was 0.6%, with no deaths within 90 days. Single-port group had a significantly shorter operative time, hospital stay, and early drainage than the multi-port group.

This study preliminarily confirms that robot-assisted segmentectomy is safe and feasible in experienced centers, with a low perioperative complication rate and favorable short-term outcomes. Robotic surgery is a safe and viable alternative to video-assisted thoracoscopic segmentectomy, although its long-term oncological efficacy requires further validation by prospective studies..

To overcome the limitations imposed by traditional wall-mounted negative pressure thoracic drainage systems on postoperative lung patients’ mobility, we developed a new portable negative pressure thoracic drainage device.

The new portable negative pressure thoracic drainage device is composed of a main unit and a three-chamber closed drainage bottle. The maximum water column height of the pressure regulating chamber of the three-chamber closed drainage bottle is approximately 20 cm. The new device adopts a split structure design: using 3D printing manufacturing, the micro air pump, rechargeable power supply and noise reduction system are integrated into an independent portable main unit, which is fixed to the side wall of the three-chamber closed drainage bottle by means of strong double-sided adhesive tape.

The main unit measures 162 mm × 108 mm × 54 mm and weighs approximately 800 g. The maximum negative pressure is about 20 cmH₂O, and the noise is less than 60 decibels at a flow rate of 3 L/min. The battery life is approximately 3 to 6 hours, and the maximum flow rate is about 9 L/min. The estimated material cost for each device is about 800 RMB, and the cost of disposable consumables (three-chamber closed drainage bottle and strong double-sided tape) is about 48 RMB.

This study developed a new type of closed thoracic drainage device, which has the engineering feasibility to achieve portable negative pressure drainage. It is expected to improve the mobility of patients who need negative pressure drainage in the thoracic cavity after lung surgery, but it still needs to be verified by clinical trials.

To explore the teaching model that combines digital Bridge-in, Objective, Pre-assessment, Participatory learning, Post-assessment, Summary (BOPPPS) with case-based learning (CBL), and evaluate its practical application effects in the clinical teaching of cardiothoracic surgery nursing.

Thirty fourth-year undergraduate nursing students rotating in the Cardiothoracic Surgery Department at Tianjin Medical University General Hospital were selected as the study subjects. They were randomly divided into an experimental group (15 students) and a control group (15 students). During the teaching process, the experimental group received instruction using an online BOPPPS combined with CBL teaching method, while the control group was taught using the traditional teaching model. After the teaching period, the teaching effectiveness of the two groups was compared and analyzed through tests and questionnaires.

The students in the experimental group outperformed those in the control group in assessments of theoretical knowledge, case analysis, and skill operations. Additionally, the experimental group reported higher satisfaction with the teaching and gave more favorable evaluations of this teaching model compared to the control group. These differences were all statistically significant (P<0.05).

The digital-based BOPPPS combined with CBL teaching model can effectively stimulate learners’ interest in learning, enhance their ability to analyze and solve clinical problems, and also help strengthen their teamwork and communication skills, providing strong support for a smooth transition to clinical work in cardiothoracic nursing. This study serves as an initial investigation with a small sample size and limited statistical power, and the generalizability of the conclusions is restricted. Future research should plan to increase the sample size and conduct multicenter studies for additional confirmation..

The success of lung cancer surgery critically depends on the precise identification of complex pulmonary anatomy and the accurate definition of surgical margins. Virtual reality (VR) technology offers a novel technical approach to addressing these key issues by creating immersive, multisensory and interactive virtual simulation environments. In the preoperative planning phase, VR technology enables non-invasive and precise lesion localization through high-fidelity 3D reconstruction and supports individualized surgical simulation, thereby optimizing surgical strategies. During intraoperative navigation, the integration of VR with augmented reality (AR) or mixed reality (MR) technologies allows for the superimposition of virtual scenes onto the real surgical field. This provides real-time spatial guidance for procedures such as lobectomy or segmentectomy and lymphadenectomy, significantly enhancing surgical precision and safety. In the realm of medical education and training, VR simulators create highly realistic surgical scenarios coupled with immediate feedback mechanisms, offering physicians a risk-free, repeatable training platform that effectively shortens the learning curve. Furthermore, as a non-pharmacological intervention, VR technology has also demonstrated positive effects in alleviating perioperative anxiety and pain in patients. This review systematically examines the specific applications and research progress of VR technology in the field of lung cancer surgery, aiming to provide references for related clinical practices and future research.

Stage ⅠA3 non-small cell lung cancer (NSCLC) represents a high-risk subgroup within early-stage lung cancer, characterized by significant prognostic heterogeneity and ongoing controversies in treatment strategies. This review systematically summarizes the prognostic features and driving factors of stage ⅠA3 NSCLC, with a focus on high-risk pathological markers such as spread through air spaces (STAS), lymphovascular invasion (LVI), and tumor-stroma ratio (TSR), and their roles in prognostic stratification. We further analyze their clinical implications in surgical extent selection and adjuvant therapy decision-making. By integrating advanced technologies such as radiomics and artificial intelligence, we discuss recent advances in preoperative prediction and postoperative personalized adjuvant therapy. We propose a precision treatment strategy based on multimodal risk models, aiming to provide evidence-based guidance for clinical practice and facilitate the transition from anatomic staging to biology-driven individualized management for stage IA3 NSCLC.

To analyze the influence factors of elevated troponin I (cTnI) in patients with acute non-traumatic cerebral hemorrhage.

A total of 138 patients with acute non-traumatic intracerebral hemorrhage admitted to The First People’s Hospital of Chun'an County from April 2022 to April 2024 were enrolled as study subjects, including 76 males and 62 females. The patients were aged 50 to 70 years, with a mean age of (58.99±5.98) years. According to the serum level of cardiac troponin I (cTnI), the patients were divided into two groups: the elevated cTnI group (cTnI≥0.04 ng/mL, n=44) and the normal cTnI group (cTnI<0.04 ng/mL, n=94). Compared with the general data of the two groups, multivariate logistic regression model was used to analyze the influencing factors of cTnI, and restricted cubic spline was used to evaluate the relationship between cTnI and prognosis.

Glasgow coma score and the estimated glomerular filtration rate (eGFR) were lower at admission in the elevated group (GCS), as compared to the normal group, The hematoma volume and hemorrhage involvement in the insula area were higher than those in the normal group (P<0.05); Multivariate logistic regression analysis showed that the risk of elevated cTnI level in patients with acute non-traumatic intracerebral hemorrhage was associated with high eGFR (OR=0.977,95% CI: 0.956~0.997), high GCS score (OR=0.272, 95% CI: 0.160~0.462), bleeding involvement of island region (OR=3.948, 95% CI: 1.139~13.679), and hematoma volume (OR=1.145, 95% CI: 1.045~1.254) (all P<0.05); Of the 138 patients, In 37 patients, the mRS scores from 4 to 6 were classified as poor prognosis. Taking the prognosis as the dependent variable, the restrictive cubic spline plot showed that with the increasing levels of cTnI, the greater the risk of having a poor prognosis was noted, with non-linear dose-response relationship between cTnI and prognosis (P<0.05).

Elevated cTnI is associated with eGFR, GCS score, hemorrhage involvement of the insula region, and hematoma volume, and cTnI levels showed a non-linear dose-response relationship with outcome in patients with acute non-traumatic ICH.

To investigate the correlation between blood pressure circadian rhythm and early neurological deterioration (END) in patients with acute small artery occlusive (SAO) cerebral infarction.

A total of 116 patients with cerebral infarction admitted to the Department of Neurology, Wujin Hospital Affiliated to Jiangsu University from January 2023 to October 2023 were enrolled as research subjects, including 79 males and 37 females, aged 48 to 87 years with a mean age of (67.83±11.12) years. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed on all 116 patients with acute SAO cerebral infarction. According to the monitoring results, the blood pressure circadian rhythm was divided into three types: dipper, non-dipper and reverse dipper. Compare whether there is a statistically significant difference in the proportion of patients developing END among the three groups, and whether the alteration of blood pressure circadian rhythm was an independent risk factor for END was analyzed.

ABPM showed that there were 23 cases in the dipper group, 52 cases in the non-dipper group and 41 cases in the reverse dipper group among the subjects. The numbers of patients who developed END in the three groups were 3, 7 and 14, respectively. There was a statistically significant difference in the incidence of END among the three groups (P<0.05). Further study revealed that the alteration of blood pressure circadian rhythm was an independent risk factor for END (P<0.05).

The alteration of blood pressure circadian rhythm is commonly found in patients with acute SAO cerebral infarction, among which the reverse dipper type is the most prevalent. Moreover, the alteration of blood pressure circadian rhythm is an independent risk factor for END.

To study the application of sequential treatment with high-flow oxygen therapy and noninvasive positive pressure ventilation in the treatment of elderly patients with chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure.

A retrospective analysis was performed on the medical records of 84 elderly patients with COPD complicated with type Ⅱ respiratory failure admitted to Nanjing Drum Tower Hospital GroupSuqian Hospital from 2022 to 2024, including 40 males and 44 females. The patients were aged 60 to 73 years, with a mean age of (62.78 ± 6.83) years. According to the ventilation method, they were divided into three groups: ventilation group, oxygen therapy group, and combination group, with 28 cases in each group. The ventilation group received non-invasive positive pressure ventilation, the oxygen therapy group received high flow oxygen therapy, and the combination group received sequential non-invasive positive pressure ventilation with high flow oxygen therapy. Forty-eight hours after treatment, the clinical efficacy and the success rate of weaning from the ventilator were compared among the three groups; After 12 hours, 24 hours, 48 hours and 72 hours of treatment, the oxygenation index and respiratory rate were compared among the three groups.

At 12, 24, 48, and 72 hours after treatment, the oxygenation index of the combination group was higher than that of the oxygen therapy group and the ventilation group, and the oxygen therapy group was higher than the ventilation group, with statistical significance (P<0.05). Before intervention, there was no statistically significant difference in respiratory rate indicators among the three groups (P>0.05). After intervention, the respiratory rate of the combination group was lower than that of the oxygen therapy group and the ventilation group, and the oxygen therapy group was lower than the ventilation group, with statistical significance (P<0.05). 48 hours after treatment, the success rate of weaning in the oxygen therapy group was 85.71% (24/28), the success rate of weaning in the combination group was 92.86% (26/28), and the weaning rate in the ventilation group was 64.29% (18/28). There was no statistically significant difference between the combination group and the oxygen therapy group, or between the oxygen therapy group and the ventilation group (P>0.05), but there was a statistically significant difference between the combination group and the ventilation group (P<0.05).

High-flow oxygen therapy is superior to noninvasive positive pressure ventilation treatment, but the sequential treatment with high-flow oxygen therapy and noninvasive positive pressure ventilation has more advantages in improving the oxygenation index, respiratory rate and the success rate of weaning from the ventilator.

To analyze and study the application effect of predictive nursing strategy and emotional nursing in patients with sudden deafness and tinnitus.

A total of 100 patients with sudden deafness and tinnitus admitted to our hospital from September, 2023 to August, 2024 were selected as the research object of this project. There were 44 males and 56 females. The age ranged from 23 to 69 years, with an average of (44.10±5.18) years.100 patients were randomly divided into observation group (n=50) and control group (n=50). Patients in the control group were intervened by conventional nursing mode during hospitalization, while patients in the observation group were intervened by predictive nursing strategy and emotional nursing mode of traditional Chinese medicine during hospitalization for 2 weeks. The symptom recovery effect, air conduction hearing threshold and tinnitus symptom score before and after nursing and psychological state of the two groups were compared.

The total effective rate of symptom recovery in the observation group was significantly higher than that in the control group (P<0.05). The threshold of hearing guidance and tinnitus symptom score in both groups showed a significant downward trend with the extension of nursing time (F_time of air-guided hearing threshold was 89.62, F_time of THI score was 95.47, F_time>F_0.05 (3.04), P<0.05). There was a significant interaction effect between grouping and nursing time (air conduction threshold F_interaction was 12.35, THI score F_interaction is 14.82, F_interaction>F_0.05 (3.04), P<0.05), which indicated that the decline of the threshold of air conduction hearing and tinnitus symptom score in the observation group was significantly superior. After two weeks of nursing, the scores of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) in the two groups were lower than those before nursing, and the scores in the observation group were lower than those in the control group at the same period (P<0.05). The recurrence rate of deafness or tinnitus in the observation group was significantly lower than that in the control group (P<0.05).

Predictive nursing and emotional nursing of traditional Chinese medicine can significantly improve the hearing recovery effect of patients with sudden deafness and tinnitus, and play a significant role in reducing the degree of tinnitus and in improving the hearing level and psychological state of patients.

To compare the efficacy and prognosis of recombinant tissue plasminogen activator (rt-PA) and Recombinant Human Tissue-Type Plasminogen Activator (TNK) for the treatment of acute cerebral infarction (AIS).

A retrospective analysis was conducted on the medical records of 103 patients with AIS who were admitted to Yangzhong People's Hospital in Jiangsu Province from January 2024 to December 2024, among them, 65 were male and 38 were female; the age ranged from 42 to 85 years, with an average of (68.19±5.78) years, and they were divided into rt-PA group (51 cases) and TNK group (52 cases) According to different treatment methods. The time from admission to thrombolysis completion, clinical efficacy, National Institutes of Health Stroke Scale (NIHSS) score, complications, modified Rankin Scale (mRS) score and the good prognosis rate at 90 days were compared between the two patient groups.

The time from admission to thrombolysis completion in the TNK group was shorter than that in the rt-PA group (P<0.05). The total effective rate of the TNK group was higher than that of the rt-PA group (P<0.05). The NIHSS scores of both patient groups decreased 24 hours after thrombolysis and 14 days after treatment, and the TNK group was lower than the rt-PA group (P<0.05). The coagulation function indicators of both patient groups increased 24 hours after thrombolysis, but the TNKgroup was lower than the rt-PA group (P<0.05). There was no difference in the total incidence of complications between the two patient groups (P>0.05). The mRS Scores of both groups 1 day before discharge and 90 days after thrombolysis were lower than those before thrombolysis, but there was no difference between the groups (P>0.05), and there was no difference in the good prognosis rate between the two patient groups (P>0.05).

rt-PA and TNK are both effective drugs for AIS thrombolysis under emergency green channel, with similar prognoses, but TNK has advantages in convenient administration and improving short-term efficacy, and clinical selection should be flexible.

To explore the clinical application value of continuous blood purification (CBP) combined with hemoperfusion (HP) in patients with severe sepsis complicated with acute respiratory distress syndrome (ARDS).

The data of 160 patients with severe sepsis complicated with ARDS admitted to the Affiliated Hospital of Shanxi University of Traditional Chinese Medicine from August 2022 to August 2024 were retrospectively selected, including 93 males and 67 females. The age ranged from 41 to 82 years with an average of (63.22±3.58) years. Based on the differences in treatment methods, the patients were divided into two groups: a control group (80 cases) and an observation group (80 cases), who received different treatment plans including conventional treatment and CBP+HP; The hemodynamic indicators, inflammatory factor levels, biochemical indicators, blood gas indicators, prognostic outcomes, and the effects on inflammatory factors [procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6)] were compared between the two groups.

After treatment, the heart rate of the two groups was lower than that of the control group (P<0.05), and the average arterial pressure of the two patient groups was higher than that of the control group (P<0.05); After treatment, both groups showed a decrease in IL-6, hs-CRP, and PCT, with the observation group showing a more significant decrease (P<0.05); After treatment, the arterial oxygen partial pressure (PaO₂) and oxygenation index (PaO₂/FiO₂) increased in both groups, especially in the observation group (P<0.05). After treatment, the levels of serum creatinine (SCr), lactate dehydrogenase (LDH) and serum lactic acid (LAC) in both groups showed a downward trend, and the decrease in the observation group was even greater (P<0.05). After treatment, the scores of acute physiology and chronic health status score system Ⅱ (APACHE Ⅱ) in both groups decreased, especially in the observation group (P<0.05).

The combined implementation of CBP and HP techniques in the treatment of severe sepsis complicated with ARDS not only regulates hemodynamics and reduces inflammatory factors, but also improves blood gas indicators and enhances patient prognosis.

To explore effects of nasal high flow oxygen therapy (HFNC) combined with high-pressure non-invasive positive pressure ventilation (NPPV) on inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and type II respiratory failure.

A retrospective analysis was conducted on the treatment of 90 patients with AECOPD combined with type II respiratory failure admitted to the Respiratory Department of Yixing Sixth People's Hospital from January 2022 to January 2025, among them, there were 47 males and 43 females; their ages ranged from 24 to 69 years, with an average of (46.82±7.61) years. The patients were divided into a control group and an observation group, with 45 patients in each group. The control group received high-pressure NPPV treatment, while the observation group received HFNC combined with high-pressure NPPV treatment. Comparative analysis of inflammatory factors [(C-reactive protein, CRP), (interleukin-17, IL-17), (tumor necrosis factor-α, TNF-α)], pulmonary function indicators [(forced vital capacity, FVC), (forced expiratory volume in the first second, FEV1), FEV1/FVC], and blood gas analysis indicators [(partial pressure of oxygen, PaO₂), (partial pressure of carbon dioxide, PaCO₂), pH] between two groups of patients upon admission and 3 days after treatment. The changes of CO₂ and blood pH levels between the two groups, including length of hospital stay, intubation rate, readmission rate after 28 days of follow-up, and treatment efficacy were compared.

At admission, there was no significant difference in the levels of inflammatory factors CRP, IL-17, and TNF-α between the two groups (P>0.05); after 3 days of treatment, the CRP, IL-17, and TNF-α decreased in both groups of patients, the inflammatory factors CRP, IL-17, and TNF-α in the observation group were lower than those in the control group (P<0.05). At admission, there was no significant difference in the lung function indicators FVC, FEV1, and FEV1/FVC between the two groups (P>0.05); after 3 days of treatment, the FVC, FEV1, and FEV1/FVC of both groups of patients increased,and the lung function indicators FVC, FEV1, and FEV1/FVC in the observation group were higher than those in the control group (P<0.05). At admission, there was no significant difference in the blood gas analysis indicators PaO₂, PaCO₂, and pH value between the two groups (P>0.05); after 3 days of treatment, the PaO₂ and pH values of both groups of patients increased significantly, while the PaCO₂ values decreased significantly,the blood gas analysis indicators PaO₂ and pH value in the observation group were higher than those in the control group, while PaCO₂ was lower than that in the control group (P<0.05). The observation group had lower hospitalization days, intubation rate, and readmission rate due to the disease after 28 days of follow-up compared to the control group (P<0.05). The total effective rate of clinical treatment in the observation group was higher than that in the control group (P<0.05).

The combination of HFNC and high-pressure NPPV in the treatment of AECOPD patients with type II respiratory failure can effectively improve lung function indicators, blood gas analysis indicators, reduce inflammatory reactions, and has good therapeutic effects, which is worth promoting.